Effects of Vinca Rosea on Liver Function in Diabetic Rats
Author Information
Author(s): Muacevic Alexander, Adler John R, Balida Mallikarjuna Rao, Vedavijaya T., Ramani Y. Roja, Chowdhury Bimalendu
Primary Institution: Roland Institute of Pharmaceutical Sciences, Berhampur
Hypothesis
Vinca rosea leaf extract has protective effects on hepatic function in STZ-induced diabetic Wistar albino rats.
Conclusion
Vinca rosea demonstrated significant hepatoprotective effects in STZ-induced diabetic rats by reducing blood glucose levels and improving liver function.
Supporting Evidence
- Vinca rosea treatment significantly reduced blood glucose in a dose-dependent manner.
- The high-dose group showed the greatest improvement in liver function markers.
- Histopathological analysis revealed near-normal liver architecture in Vinca rosea-treated groups.
Takeaway
This study shows that a plant called Vinca rosea can help protect the liver and lower blood sugar in diabetic rats.
Methodology
Thirty male Wistar albino rats were divided into five groups and treated with Vinca rosea or metformin for 30 days after inducing diabetes with STZ.
Limitations
The study was conducted in an animal model, did not isolate specific bioactive compounds, and only covered a 30-day treatment period.
Participant Demographics
Thirty male Wistar albino rats, weighing between 200 and 250 g.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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