Dimethylamine Borane Neurotoxicity
2006
Neurotoxicity of Dimethylamine Borane
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Huang Chin-Chang, Kuo Hung-Chou
Primary Institution: Chang Gung Memorial Hospital
Hypothesis
What are the neurologic effects of dimethylamine borane (DMAB) poisoning?
Conclusion
The study suggests that DMAB has prolonged toxic effects on cognitive functions and causes acute axonal polyneuropathy.
Supporting Evidence
- The patient showed no cerebellar signs one month after DMAB intoxication.
- Follow-up brain MRI showed nearly normal results six weeks after intoxication.
- The patient had cognitive impairments in various memory and attention functions fourteen weeks after exposure.
- Nerve conduction studies confirmed axonal polyneuropathy.
Takeaway
One patient who took a chemical called DMAB had serious brain and nerve problems, but some of those problems got better over time.
Methodology
The study involved neurologic examinations, brain MRI, neuropsychological assessments, and nerve conduction studies.
Limitations
The findings are based on a single case study, which may not be generalizable.
Participant Demographics
One male patient evaluated after DMAB intoxication.
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