Probiotic Limosilactobacillus fermentum YZ01 Helps Fight Malaria in Mice
Author Information
Author(s): Timothy Bamgbose, Afshana Quadri, Abdullahi Isa O., Inabo Helen I., Bello Mohammed, Kori Lokesh D., Anvikar Anupkumar R., José de la Fuente, Elianne Piloto-Sardiñas, Alejandro Cabezas-Cruz
Primary Institution: ICMR-National Institute of Malaria Research
Hypothesis
Oral administration of L. fermentum YZ01 could modulate the immune system and gut microbiota in a way that reduces the severity of malaria infection.
Conclusion
The study found that probiotic treatment significantly reduced parasitaemia and improved survival rates in mice infected with malaria.
Supporting Evidence
- Probiotic treatment significantly altered gut microbiota, increasing LAB counts.
- Mice receiving probiotics showed delayed parasitaemia onset and reduced mortality rates.
- Probiotics enhanced immune responses, increasing IgM and IL-4 production while reducing IFN-γ levels.
Takeaway
Giving mice a special yogurt with probiotics helped them fight off malaria better and made them live longer.
Methodology
The study involved feeding BALB/c mice with probiotic yogurt and assessing their immune response, parasitaemia, and survival rates after infection with Plasmodium berghei ANKA.
Potential Biases
Potential bias in the selection of treatment groups and the controlled nature of the study may limit generalizability.
Limitations
The study was conducted in a controlled environment with a specific mouse model, which may not fully represent human responses.
Participant Demographics
Male BALB/c mice, aged 6–8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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