The Evolution of Kidney Graft Preservation Through the Years
Author Information
Author(s): Calva Lopez Andres, Robles Garcia Jose Enrique, Yanez Ruiz Carlos Andres, Tapia Tapia Mario Daniel, Talavera Cobo Vanessa, Muñoz Bastidas Carmina Alejandra, Sanchez Zalabardo Daniel, Miñana Lopez Bernardino, Ietto Giuseppe, Di Bella Caterina
Primary Institution: Clínica Universidad de Navarra
Conclusion
Kidney graft preservation methods have evolved significantly, with hypothermic machine perfusion showing superior outcomes compared to static cold storage.
Supporting Evidence
- Hypothermic machine perfusion reduces the risk of delayed graft function by 43% compared to static cold storage.
- 1-year graft survival rates are superior with hypothermic machine perfusion compared to static cold storage.
- A Cochrane meta-analysis found that hypothermic machine perfusion reduces the incidence of delayed graft function across donor types.
Takeaway
This study looks at how to keep kidney transplants healthy before they are used, showing that new methods work better than old ones.
Methodology
The review summarizes various kidney graft preservation methods and their outcomes, including static cold storage and hypothermic machine perfusion.
Limitations
The review does not provide new experimental data but summarizes existing studies.
Statistical Information
P-Value
p = 0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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