Intensive Care Outcomes in Bone Marrow Transplant Recipients
Author Information
Author(s): Damon C. Scales, Deva Thiruchelvam, Alexander Kiss, William J. Sibbald, Donald A. Redelmeier
Primary Institution: Sunnybrook Health Sciences Centre
Hypothesis
What are the long-term outcomes of bone marrow transplant recipients admitted to an ICU during subsequent hospitalizations?
Conclusion
The prognosis of bone marrow transplant recipients receiving ICU care during subsequent hospitalizations is very poor but should not be considered futile.
Supporting Evidence
- 87% of patients receiving mechanical ventilation died within 1 year.
- 91% of patients receiving pulmonary artery catheterization died within 1 year.
- 94% of patients receiving hemodialysis died within 1 year.
- Death rates at 1 year were highest for those receiving major ICU procedures.
- Survivors required hospitalization multiple times during the first year following transplant.
Takeaway
Patients who had a bone marrow transplant and later needed ICU care often do not survive, but some can still recover.
Methodology
A population-based cohort analysis of adult bone marrow transplant recipients who received subsequent ICU care in Ontario, Canada from 1 January 1992 to 31 March 2002.
Potential Biases
No specific risks of bias were mentioned.
Limitations
The study lacks information on specific reasons for ICU admission and other factors influencing prognosis.
Participant Demographics
Mean age was 43 years, with 60% receiving allogeneic transplants.
Statistical Information
P-Value
<0.0001
Confidence Interval
95% confidence interval for odds ratios provided in the results.
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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