Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion
2008
Effects of ECE-1 Isoforms on Prostate Cancer Cell Invasion
publication
Evidence: moderate
Author Information
Author(s): Lambert L A, Whyteside A R, Turner A J, Usmani B A
Primary Institution: University of Leeds
Hypothesis
How do different isoforms of endothelin-converting enzyme-1 (ECE-1) affect prostate cancer cell invasion?
Conclusion
The study found that ECE-1a suppresses and ECE-1c promotes prostate cancer cell invasion.
Supporting Evidence
- Knockdown of stromal ECE-1 reduced prostate cancer cell invasion.
- Transient overexpression of ECE-1c increased invasiveness of prostate cancer cells.
- ECE-1a expression in stromal cells counteracted the effect of ECE-1c on cancer cell invasion.
Takeaway
Some parts of a protein called ECE-1 can help cancer cells move around, while others can stop them from moving.
Methodology
The study used siRNA to knock down ECE-1 expression and measured the invasion of prostate cancer cells through matrigel.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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