Repeated Praziquantel Dosing for Schistosomiasis Treatment
Author Information
Author(s): King Charles H., Olbrych Stephanie K., Soon Margaret, Singer Mendel E., Carter Jen, Colley Daniel G.
Primary Institution: Case Western Reserve University School of Medicine
Hypothesis
In high-risk communities, repeated praziquantel dosing may provide incremental benefits over single dosing for schistosomiasis treatment.
Conclusion
Repeated praziquantel dosing can improve cure rates and reduce infection intensity, particularly for Schistosoma mansoni.
Supporting Evidence
- Two doses of praziquantel improved cure rates for S. mansoni from 42-79% to 69-91%.
- Reduction in egg counts was greater for S. mansoni with two doses compared to one.
- Cost-effectiveness analysis showed benefits of double dosing in school-based programs.
Takeaway
Giving a second dose of medicine can help people get better from a worm infection more than just giving one dose.
Methodology
Systematic review of studies comparing single vs. repeated praziquantel dosing for Schistosoma infections.
Potential Biases
Potential biases in study selection and reporting may affect the results.
Limitations
The analysis is based on a limited number of studies and may not fully represent real-world scenarios.
Participant Demographics
Studies included participants from various high-risk communities in Africa.
Statistical Information
P-Value
p<0.05
Confidence Interval
CI95% 2.59, 3.78
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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