Organic Papers
2011
Characterization of a Mefloquine-Oxazolidine Derivative
publication
Evidence: moderate
Author Information
Author(s): Gonçalves Raoni S. B., Kaiser Carlos R., de Souza Marcus V. N., Wardell James L., Wardell Solange M. S. V., Tiekink Edward R. T.
Primary Institution: Fundação Oswaldo Cruz, Instituto de Tecnologia, em Fármacos–Farmanguinhos
Conclusion
The study successfully characterized a mefloquine-oxazolidine derivative using X-ray crystallography.
Supporting Evidence
- The oxazoline ring adopts an envelope conformation.
- The piperidine ring has a chair conformation.
- An intramolecular O—H⋯N hydrogen bond is present.
- Crystal packing features C—H⋯O, C—H⋯F, and C—H⋯π interactions.
Takeaway
Scientists studied a new compound related to a malaria drug and found out how its atoms are arranged.
Methodology
The compound was prepared and recrystallized from ethanol for structural study using X-ray crystallography.
Digital Object Identifier (DOI)
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