Effects of Clonidine with Bupivacaine in Cesarean Section
Author Information
Author(s): Nikhil Kothari, Jaishri Chaudhary, Ajay K.
Primary Institution: CSMMU (erstwhile KGMC), Lucknow, Uttar Pradesh, India
Hypothesis
Does adding intrathecal clonidine to bupivacaine improve analgesia during cesarean sections?
Conclusion
Intrathecal clonidine provides effective analgesia and motor paralysis at a lower dose of bupivacaine, with some sedation in the postoperative period.
Supporting Evidence
- Adding clonidine reduced the required dose of bupivacaine for effective analgesia.
- Patients receiving clonidine had longer-lasting pain relief compared to those who did not.
- Sedation was observed in a significant percentage of patients receiving clonidine.
Takeaway
This study shows that adding a small amount of clonidine to a common pain medicine can help moms feel less pain after surgery while using less of the medicine.
Methodology
A randomized single-blind trial with 210 pregnant females undergoing cesarean sections, divided into three groups receiving different combinations of bupivacaine and clonidine.
Potential Biases
Patients were unaware of the drug combination received, reducing bias regarding postoperative analgesia.
Limitations
The study did not include complicated pregnancies and may not be generalizable to all patients.
Participant Demographics
210 ASA I-II pregnant females undergoing emergency cesarean section.
Statistical Information
P-Value
0.021
Confidence Interval
238.01-257.40
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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