Gene Expression Profiling of Oral Cavity Cancers
Author Information
Author(s): Severino Patricia, Alvares Adriana M, Michaluart Pedro Jr, Okamoto Oswaldo K, Nunes Fabio D, Moreira-Filho Carlos A, Tajara Eloiza H
Primary Institution: Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, SP, Brazil
Hypothesis
This study investigates the molecular differences in gene expression profiles of oral squamous cell carcinoma (OSCC) samples from different anatomic subsites.
Conclusion
The study confirms that there are significant molecular differences between OSCC subsites, which could impact the development of targeted therapies.
Supporting Evidence
- Samples clustered mostly according to disease subsite, indicating molecular heterogeneity.
- Significant molecular differences were found between OSCC anatomic subsites.
- Gene expression-based classification is important for developing targeted therapies.
Takeaway
Researchers looked at cancer samples from different parts of the mouth and found that they behave differently, which is important for treatment.
Methodology
Gene expression profiles were analyzed using whole-genome microarray technology, with samples clustered based on disease subsite.
Limitations
The study is preliminary and based on a small number of samples.
Participant Demographics
All participants were male patients with a history of tobacco and alcohol abuse.
Statistical Information
P-Value
1.55E-07
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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