MAGE-C1/CT7 and MAGE-C2/CT10 Predict Lymph Node Metastasis in Melanoma Patients
Author Information
Author(s): Curioni-Fontecedro Alessandra, Nuber Natko, Mihic-Probst Daniela, Seifert Burkhardt, Soldini Davide, Dummer Reinhard, Knuth Alexander, van den Broek Maries, Moch Holger
Primary Institution: University Hospital, Zurich, Switzerland
Hypothesis
The expression of MAGE-C1/CT7 and MAGE-C2/CT10 in primary melanoma is a predictor of lymph node metastasis.
Conclusion
The expression of MAGE-C1/CT7 and MAGE-C2/CT10 in primary melanoma is a strong predictor of sentinel lymph node metastasis.
Supporting Evidence
- MAGE-C1/CT7 was expressed in 24% of primary melanomas and 40% of metastases.
- MAGE-C2/CT10 was expressed in 33% of primary melanomas and 40% of metastases.
- Patients with MAGE-C1/CT7 positive primary melanoma had significantly more lymph node metastases (p=0.005).
- MAGE-C2/CT10 positive primary melanomas showed significantly more lymph node involvement (p<0.001).
Takeaway
This study found that certain proteins in melanoma can help doctors know if the cancer has spread to the lymph nodes, which is important for treatment.
Methodology
Immunohistochemical staining of tissue microarrays consisting of 222 melanoma lesions and 68 melanoma cell lines was performed.
Limitations
The study did not correlate MAGE expression with overall survival.
Participant Demographics
Patients with primary malignant melanoma and melanoma metastases from the University Hospital of Zurich.
Statistical Information
P-Value
p=0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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