Anti-Inflammatory Effects of Averrhoa carambola in Mice
Author Information
Author(s): Cabrini Daniela Almeida, Moresco Henrique Hunger, Imazu Priscila, da Silva Cíntia Delai, Pietrovski Evelise Fernandes, Mendes Daniel Augusto Gasparin Bueno, Prudente Arthur da Silveira, Pizzolatti Moacir Geraldo, Brighente Inês Maria Costa, Otuki Michel Fleith
Primary Institution: Universidade Federal do Paraná
Hypothesis
Does the ethanolic extract of Averrhoa carambola have anti-inflammatory effects on skin inflammation in mice?
Conclusion
The ethanolic extract of Averrhoa carambola significantly reduces skin inflammation in mice.
Supporting Evidence
- The ethanolic extract reduced edema in a dose-dependent manner, achieving a maximum inhibition of 73 ± 3%.
- The ID50 value for the ethanolic extract was 0.05 mg/ear.
- All tested fractions inhibited edema formation and myeloperoxidase activity.
- The ethyl acetate fraction was the most effective, with 75 ± 5% inhibition of edema.
Takeaway
This study found that a plant called Averrhoa carambola can help reduce swelling and inflammation in the skin of mice.
Methodology
The study used a croton oil-induced ear edema model in mice to measure the anti-inflammatory effects of the ethanolic extract and its fractions.
Limitations
The study primarily focused on mice, and results may not directly translate to humans.
Participant Demographics
Swiss male mice, 25–35 g.
Statistical Information
P-Value
p<0.05
Confidence Interval
0.02–0.13
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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