Genetic Variation in SGNE1 and Its Impact on Obesity and Glucose Intolerance
Author Information
Author(s): Bouatia-Naji Nabila, Vatin Vincent, Lecoeur Cécile, Heude Barbara, Proença Christine, Veslot Jacques, Jouret Béatrice, Tichet Jean, Charpentier Guillaume, Marre Michel, Balkau Beverley, Froguel Philippe, Meyre David
Primary Institution: CNRS-8090-Institute of Biology, Pasteur Institute, Lille, France
Hypothesis
SGNE1 is a positional candidate gene for obesity and metabolic disorders in French Caucasians.
Conclusion
SGNE1 genetic variation does not contribute to obesity and common forms of T2D but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity.
Supporting Evidence
- SNP -1,701A>G was associated with higher glucose levels after an oral glucose tolerance test.
- SNP -1,701A>G was linked to higher HOMA-IR in both obese children and adults.
- No significant association was found between SGNE1 SNPs and severe forms of obesity.
Takeaway
This study looked at a gene related to obesity and found that while it doesn't cause obesity, it might make it harder for some people to handle sugar in their blood.
Methodology
The study involved genotyping 12 SNPs in a large cohort of obese children and adults, type 2 diabetics, and controls, followed by case-control analyses.
Limitations
SNP tagging was based on data from HapMap phase I, which may not provide comprehensive coverage.
Participant Demographics
The study included 1,229 obese individuals (534 children and 695 adults), 1,535 individuals with type 2 diabetes, and 1,363 controls, all French Caucasians.
Statistical Information
P-Value
0.0005
Confidence Interval
95%CI [0.55–1.01]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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