Resveratrol Induces Apoptosis in Diffuse Large B Cell Lymphoma Cells
Author Information
Author(s): Hussain Azhar R. Uddin, Shahab Bu Rong Khan, Omar S. Ahmed, Saeeda O. Ahmed, Maqbool Al-Kuraya, Khawla S.
Primary Institution: Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Hypothesis
Resveratrol inhibits cell viability and induces apoptosis in DLBCL cells via inactivation of the AKT pathway and generation of ROS.
Conclusion
Resveratrol may have a therapeutic role in DLBCL by inducing apoptosis through ROS generation and AKT pathway suppression.
Supporting Evidence
- Resveratrol treatment inhibited cell viability in DLBCL cells.
- Apoptosis was confirmed by DNA laddering tests showing chromosomal DNA fragmentation.
- Resveratrol caused ROS release, which was essential for its pro-apoptotic effects.
- Combination treatment with Resveratrol and TRAIL enhanced apoptosis in DLBCL cells.
Takeaway
Resveratrol, a compound found in grapes, can help kill cancer cells by making them die and stopping them from growing.
Methodology
The study involved treating DLBCL cell lines with Resveratrol and measuring cell viability and apoptosis through various assays.
Limitations
The study primarily focuses on in vitro results, which may not fully translate to in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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