Inflammation and Bone Formation in Ankylosing Spondylitis
Author Information
Author(s): Baraliakos Xenofon, Listing Joachim, Rudwaleit Martin, Sieper Joachim, Braun Juergen
Primary Institution: Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum
Hypothesis
The study investigates whether and how spinal inflammation is associated with new bone formation in ankylosing spondylitis.
Conclusion
The study suggests that while inflammation is linked to new bone formation in ankylosing spondylitis, some new bone formation occurs without prior inflammation.
Supporting Evidence
- Inflammation was present in 16.6% of vertebral edges at baseline.
- Syndesmophytes developed more frequently in vertebral edges with inflammation at baseline.
- New lesions developed in 8% of vertebral edges without inflammation at baseline.
Takeaway
This study looked at how inflammation in the spine affects new bone growth in people with a disease called ankylosing spondylitis. It found that inflammation can lead to new bone growth, but sometimes new bone forms even when there is no inflammation.
Methodology
The study analyzed spinal MRI and radiographs from 39 patients treated with anti-TNF agents at baseline and after 2 years.
Potential Biases
Potential bias may arise from the selection of patients who were already receiving anti-TNF therapy.
Limitations
The study's findings are based on a relatively small sample size and may not be generalizable to all patients with ankylosing spondylitis.
Participant Demographics
Patients diagnosed with ankylosing spondylitis according to modified New York criteria, treated with anti-TNF agents.
Statistical Information
P-Value
0.002
Confidence Interval
1.5 to 7.4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website