Ejaculatory Disorders and Tamsulosin Therapy
Author Information
Author(s): Grasso Marco, Fortuna Flavio, Lania Caterina, Blanco Salvatore
Primary Institution: Department of Urology, Desio Hospital, Milan, Italy
Hypothesis
Does tamsulosin cause retrograde ejaculation disorder?
Conclusion
Tamsulosin may induce retrograde ejaculation but not other ejaculatory disorders due to abnormal sperm progression.
Supporting Evidence
- Spermatozoa were found in post-coital urine of 6 out of 10 patients.
- Contractile activity induced by norepinephrine after tamsulosin incubation in rat prostatic vas deferens strips is similar to that in human strips.
- Patients reported normal erectile and ejaculatory activity despite reduced ejaculate volume.
Takeaway
This study looked at how a medicine called tamsulosin affects ejaculation. It found that tamsulosin can cause a problem where sperm goes backward instead of out.
Methodology
The study involved in vitro evaluation of human and rat vas deferens contractile activity and a clinical trial on 10 patients with anejaculation.
Limitations
The study's sample size was small, and the results may not be generalizable to all patients.
Participant Demographics
Patients aged 48-72 years with anejaculation.
Digital Object Identifier (DOI)
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