Estimating Kidney Function in Cancer Patients
Author Information
Author(s): Wright J G, Boddy A V, Highley M, Fenwick J, McGill A, Calvert A H
Primary Institution: University of Newcastle
Hypothesis
Can a simple and reliable method be developed to estimate glomerular filtration rate (GFR) using readily-available patient characteristics?
Conclusion
The new formula for estimating GFR is less biased and more precise than existing methods.
Supporting Evidence
- The new formula produced estimates of GFR which were less biased (Mean Prediction Error = –3%) and more precise (Mean Absolute Prediction Error = 12%) than existing methods.
- Females had lower 51Cr-EDTA clearance than males.
- The enzymatic method of serum creatinine assay gave more reliable results than the Jaffe colorimetric method.
Takeaway
Doctors can use a new formula to better estimate how well a cancer patient's kidneys are working, which helps in giving the right amount of medicine.
Methodology
Data from 62 patients were analyzed to develop a formula for estimating GFR, which was then validated with an additional 38 patients.
Participant Demographics
Patients included both males and females, with noted differences in GFR estimates.
Digital Object Identifier (DOI)
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