Trends in Endometrial Cancer Incidence in the UK
Author Information
Author(s): Evans T, Sany O, Pearmain P, Ganesan R, Blann A, Sundar S
Primary Institution: West Midlands Cancer Intelligence Unit, University of Birmingham
Hypothesis
This study investigates the observed incidence trends of the two types of endometrial cancer and their distribution by age, stage, and socioeconomic factors.
Conclusion
The increase in endometrial cancer incidence is confined to type 1 cancers, particularly in the 60-79 age groups, while survival rates for type 2 cancers have significantly decreased.
Supporting Evidence
- Increased incidence of type 1 endometrial cancer was observed from 12.0 per 100,000 in 1994 to 16.3 per 100,000 in 2006.
- Type 2 cancer incidence remained static at 2.5 per 100,000 in 1994 and 2.2 per 100,000 in 2006.
- 1-year survival for type 2 cancer showed no significant improvement, remaining around 73.1% to 74.3%.
Takeaway
More women are getting type 1 endometrial cancer, especially those aged 60 to 79, but type 2 cancer is not getting better and is actually getting worse.
Methodology
Data were analyzed from 6867 women with endometrial cancer registered between 1994 and 2006 at a UK population-based cancer registry.
Potential Biases
Potential bias due to incomplete data on stage and ethnicity.
Limitations
The study was limited to data from one cancer registry and lacked robust analysis of ethnicity and socioeconomic differences in survival.
Participant Demographics
Women diagnosed with endometrial cancer in the West Midlands, UK, from 1994 to 2006.
Statistical Information
P-Value
p<0.001
Confidence Interval
CI 10.7–13.2 to CI 14.9–17.7
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website