Over-expression of the c-myc proto-oncogene in colorectal carcinoma
Author Information
Author(s): D.R. Smith, T. Myint, H.-S. Goh
Primary Institution: Singapore General Hospital
Hypothesis
The study aimed to examine the oncogenic changes occurring in an Asian population with a rising incidence of colorectal cancer and to determine correlations between c-myc expression and clinical factors.
Conclusion
The study found that 66% of colorectal tumors showed over-expression of c-myc RNA, but this did not correlate with tumor stage, age, or sex.
Supporting Evidence
- 66% of colorectal tumors showed over-expression of c-myc RNA.
- Over-expression did not correlate with tumor stage.
- A significant correlation was found between c-myc over-expression and the presence of synchronous adenomas.
Takeaway
In a study of 100 colorectal cancer patients, most tumors had high levels of a gene called c-myc, but this didn't seem to affect how advanced the cancer was.
Methodology
The study analyzed RNA expression, gene amplification, and rearrangements in tumor samples from colorectal cancer patients.
Limitations
The study did not find correlations between c-myc over-expression and patient survival or disease recurrence.
Participant Demographics
The study included 55 male and 45 female patients, with an average age of 62 years, predominantly Chinese (92 patients).
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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