Cytotoxicity of Gold Complexes Against Cancer Cells
Author Information
Author(s): Dick de Vos, Soo Yei Ho, Edward R.T. Tiekink
Primary Institution: Medical Department, Pharmachemie B. V., Haarlem, The Netherlands; Department of Chemistry, National University of Singapore
Hypothesis
Phosphinegold(I) dithiocarbamates and xanthates have potential anti-tumor activity.
Conclusion
Phosphinegold(I) dithiocarbamates show greater cytotoxicity than cisplatin against various human cancer cell lines.
Supporting Evidence
- The most active complex was Et3PAu(S2CNEt2), which was more effective than cisplatin.
- Dithiocarbamate derivatives were consistently more active than xanthate counterparts.
- The study included a panel of seven human cancer cell lines for testing.
- Results indicated that dithiocarbamate complexes had lower ID50 values than standard anti-cancer agents like 5-fluorouracil and etoposide.
Takeaway
The study tested new gold compounds to see if they can kill cancer cells, and found that some are better than a common cancer drug called cisplatin.
Methodology
The cytotoxicity was evaluated using the microculture sulforhodamine B (SRB) test on seven human cancer cell lines.
Limitations
Some complexes did not dissolve completely, which may affect the results.
Want to read the original?
Access the complete publication on the publisher's website