Semi-allogeneic vaccines and tumor-induced immune tolerance
2009
Semi-Allogeneic Vaccines and Tumor-Induced Immune Tolerance
Sample size: 20
publication
Evidence: high
Author Information
Author(s): Yu Jin, Kindy Mark S, Gattoni-Celli Sebastiano
Primary Institution: Medical University of South Carolina
Hypothesis
Can semi-allogeneic vaccines protect against tumor-induced immune tolerance?
Conclusion
Semi-allogeneic vaccines can activate immune responses and block tumor-induced immune tolerance.
Supporting Evidence
- Vaccinated mice showed significantly better survival rates compared to mock-vaccinated mice.
- Gene expression analysis indicated activation of immune responses in vaccinated mice.
- Vaccination with semi-allogeneic hybrids prevented tumor growth in the majority of treated mice.
Takeaway
This study shows that a special type of vaccine made from tumor cells can help the body fight cancer better by stopping tumors from tricking the immune system.
Methodology
Mice were vaccinated with semi-allogeneic cell hybrids and then challenged with tumor cells to assess protection.
Participant Demographics
C57BL/6 male mice were used in the study.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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