Helicobacter Species in Biliary Tract Cancer
Author Information
Author(s): de Martel C, Plummer M, Parsonnet J, van Doorn L-J, Franceschi S
Primary Institution: International Agency for Research on Cancer
Hypothesis
Are Helicobacter species linked to biliary tract cancers?
Conclusion
The study suggests that Helicobacter species may be more frequently found in biliary tract cancer patients compared to controls, but results vary widely across studies.
Supporting Evidence
- Nine studies of biliary tract cancers were identified, all with 30 or fewer cases.
- Four studies found Helicobacter species in cancer patients significantly more often than in controls.
- Two studies reported no Helicobacter species detected in either cases or controls.
Takeaway
This study looked at whether certain bacteria called Helicobacter are found more often in people with biliary tract cancer compared to those without it.
Methodology
The authors conducted a literature review of studies examining Helicobacter species in bile or biliary tract biopsies from cancer patients.
Potential Biases
Variability in study methods and small sample sizes may introduce bias.
Limitations
The study relies on a few small studies with substantial differences in methods and results.
Participant Demographics
The studies included patients with biliary tract cancers and benign diseases from various countries.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% confidence interval: 1.4–70.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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