Amyloid beta Precursor Protein's Role in Neuron Stress Response
Author Information
Author(s): Giliberto Luca, Zhou Dawang, Weldon Richard, Tamagno Elena, De Luca Pasquale, Tabaton Massimo, D'Adamio Luciano
Primary Institution: Albert Einstein College of Medicine
Hypothesis
Does the APP intracellular domain lower the stress threshold of neurons and influence gene transcription?
Conclusion
The APP intracellular domain may increase neuronal sensitivity to toxic stimuli without affecting the expression of certain target genes.
Supporting Evidence
- AID does not regulate the basal expression of APP, NEP, KAI1, and p53 in the adult mouse brain.
- Transgenic mice expressing AID showed increased sensitivity to toxic stimuli.
- LDH release indicated higher cell damage in AID positive neurons under stress.
Takeaway
This study found that a part of a protein related to Alzheimer's disease makes brain cells more sensitive to damage, but it doesn't change how certain genes work.
Methodology
Transgenic mice expressing the APP intracellular domain were analyzed for gene expression and susceptibility to stress.
Limitations
The study did not identify specific AID target genes and results may vary under different conditions.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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