Maternal Antibody Transfer in Preterm and Full-term Infants
Author Information
Author(s): Kalee E Rumfelt, Mindy Pike, Jennifer E Stolarczuk, Ava Lekander, Adam S Lauring, Linda O Eckert, Janet A Englund, Emily T Martin, Alisa B Kachikis
Primary Institution: University of Washington
Hypothesis
How does maternal vaccination affect the transfer of antibodies to preterm and full-term infants?
Conclusion
Maternal vaccination enhances the transfer of antibodies to infants, particularly benefiting preterm infants.
Supporting Evidence
- Approximately 70% of pregnant persons received the influenza vaccine.
- Preterm infants had significantly lower cord to maternal IgG transfer ratios for IAV-H3 and RSV compared to full-term infants.
- Maternal and cord antibody concentrations were highest in the influenza-vaccinated group.
Takeaway
When moms get vaccinated, they can pass on more antibodies to their babies, which helps keep them safe from getting sick.
Methodology
Delivery samples from 115 maternal-infant pairs were analyzed for RSV and influenza antibodies using electrochemiluminescence assays.
Potential Biases
Potential conflicts of interest were noted for some authors related to consulting and funding.
Limitations
The study could not document prior infections with influenza or RSV, which may influence antibody concentrations.
Participant Demographics
Participants included pregnant individuals with singleton pregnancies, with a majority being vaccinated against influenza.
Statistical Information
P-Value
p ≤ 0.05
Statistical Significance
p ≤ 0.05
Digital Object Identifier (DOI)
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