Systemic Cancer and the FAMMM Syndrome
Author Information
Author(s): W. Bergman, P. Watson, J. de Jong, H.T. Lynch, R.M. Fusaro
Primary Institution: University Medical Centre Leiden and Creighton University School of Medicine
Hypothesis
Is there an increased susceptibility to non-melanoma cancers in families with the FAMMM syndrome?
Conclusion
The study found evidence of increased susceptibility to systemic cancer, particularly digestive tract cancer, in a subset of FAMMM families.
Supporting Evidence
- 43 extracutaneous cancers were reported among the 200 high risk family members studied.
- Significant excess of digestive system cancer, especially pancreatic cancer, was found in the nine families.
- Three of the nine families had a marked excess in numbers of systemic cancers.
Takeaway
Some families with a genetic condition called FAMMM are more likely to get certain types of cancer, especially in the digestive system.
Methodology
Clinical and genetic studies were performed on well-documented FAMMM families, including interviews and examinations for cancer occurrences.
Potential Biases
Potential bias in family selection and reporting of cancer diagnoses.
Limitations
The study may have biases due to family selection and the reliance on self-reported cancer diagnoses.
Participant Demographics
Families ascertained in a pigmented lesions clinic in the Netherlands.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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