Comparing Stress Responses in Yeast to Antimycin A and Oxygen Deprivation
Author Information
Author(s): Lai Liang-Chuan, Kissinger Matthew T, Burke Patricia V, Kwast Kurt E
Primary Institution: Department of Physiology, National Taiwan University College of Medicine
Hypothesis
What are the functional and regulatory aspects of the stress responses elicited by antimycin A and oxygen deprivation in yeast?
Conclusion
The study differentiates between gene networks responding to respiratory inhibition and those responding to oxygen deprivation, suggesting that the environmental stress response balances energy supply and demand while coordinating growth with the cell cycle.
Supporting Evidence
- 1754 genes responded significantly to anaerobiosis, while 901 responded to antimycin A treatment.
- Gene network analyses revealed that both treatments resulted in down-regulation of networks involved in the cell cycle.
- Transient up-regulation of networks involved in energy regulation and autophagy was observed during stress responses.
Takeaway
When yeast cells face stress from lack of oxygen or a chemical called antimycin A, they change how they use energy and grow. This helps them survive tough conditions.
Methodology
The study used gene network analyses and statistical comparisons of transcriptomic responses to antimycin A treatment and anaerobiosis over several generations.
Limitations
The study primarily focuses on specific conditions in yeast and may not generalize to other organisms or stress types.
Participant Demographics
The study used the yeast strain Saccharomyces cerevisiae.
Statistical Information
P-Value
p ≤ 0.01
Statistical Significance
p ≤ 0.01
Digital Object Identifier (DOI)
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