Blood Metals and Cardiovascular Diseases
Author Information
Author(s): Li Bin, Liu Haiyue, Mishra Devrakshita, Yuan Zhen, Zhang Yizhi, Zhang Longzhen, Huang Yanshu, Zhang Ye, Lin Ju, Chen Jianyou, Liu Zuheng
Primary Institution: Xiamen Chang Gung Hospital, School of Medicine, Huaqiao University
Hypothesis
This study aims to explore the roles of specific blood metals and develop a model to differentiate between healthy participants and CVD patients.
Conclusion
Blood metals may play an important role in the onset and progression of cardiovascular diseases and can be used to develop a predictive model for early diagnosis.
Supporting Evidence
- Blood lead levels were significantly higher in CVD patients compared to non-CVD participants.
- Higher blood cadmium levels were associated with increased odds of CVD.
- Blood selenium appeared to be a protective factor against CVDs.
- The predictive model using blood metals achieved an AUC of 0.91.
Takeaway
This study found that certain metals in the blood, like lead and cadmium, can increase the risk of heart problems, while selenium can help protect against them.
Methodology
Data from NHANES 2011–2020 were analyzed using logistic regression and random forest analyses to assess the relationship between blood metals and cardiovascular diseases.
Potential Biases
Potential bias due to missing data on smoking status.
Limitations
The study is cross-sectional, which may not provide definitive causal relationships, and only five blood metals were analyzed.
Participant Demographics
Mean age of participants was 50.32 years, with 48.5% males; most were Non-Hispanic White and had a high level of education.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 1.022–1.035
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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