Centrosome and retroviruses: The dangerous liaisons
2007
Centrosome and Retroviruses: The Dangerous Liaisons
publication
Author Information
Author(s): Afonso Philippe V, Zamborlini Alessia, Saïb Ali, Mahieux Renaud
Primary Institution: Institut Pasteur
Hypothesis
How do retroviruses interact with centrosomes and affect their functions?
Conclusion
Retroviruses hijack centrosome functions, leading to genetic instability and potential tumorigenesis.
Supporting Evidence
- Centrosomes are crucial for cell organization and function.
- Retroviruses like HIV-1 and HTLV-1 can disrupt centrosome functions.
- Centrosome amplification is linked to genetic instability and cancer.
Takeaway
Some viruses, like HIV, use a part of the cell called the centrosome to help them replicate, which can cause problems for the cell.
Digital Object Identifier (DOI)
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