Isotretinoin and Psychiatric Side Effects: A Review
Author Information
Author(s): Kontaxakis Vassilis P, Skourides Demetris, Ferentinos Panayotis, Havaki-Kontaxaki Beata J, Papadimitriou George N
Primary Institution: Athens University Medical School, First Department of Psychiatry, Eginition Hospital, Athens, Greece
Hypothesis
What is the association between isotretinoin use and psychiatric side effects?
Conclusion
The evidence suggests a link between isotretinoin use and various psychiatric side effects, although a causal relationship has not been firmly established.
Supporting Evidence
- There are numerous reports linking isotretinoin to depression and suicidality.
- Isotretinoin ranked 4th in the FDA's list of drugs associated with depression.
- Psychiatric side effects are reported to be higher for isotretinoin compared to other acne treatments.
Takeaway
Isotretinoin, a medication for acne, might cause mood problems like depression and suicidal thoughts in some people.
Methodology
The study reviewed published material on psychiatric side effects following isotretinoin treatment, including case reports and studies.
Potential Biases
Potential biases may arise from the retrospective nature of many studies and the reliance on self-reported data.
Limitations
The lack of double-blind, placebo-controlled studies and methodological flaws in existing literature limit the ability to establish a causal link.
Digital Object Identifier (DOI)
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