Lactate Levels and Survival in Septic Shock
Author Information
Author(s): Omar S, Mathivha, Dulhunty J, Lundgren A
Primary Institution: University of Witwatersrand, Johannesburg, South Africa
Hypothesis
Can blood lactate levels predict survival in patients with septic shock?
Conclusion
Higher lactate levels after adrenaline treatment may indicate a better chance of survival.
Supporting Evidence
- Lactate increased from 2.3 to 2.9 mmol/l.
- Peak lactate correlated with peak adrenaline.
- Lactate index was the only independent predictor of survival after controlling for age and APACHE II score.
Takeaway
Doctors measured lactate levels in patients with septic shock to see if it could help predict who would survive. They found that higher lactate levels after treatment might actually be a good sign.
Methodology
Blood lactate levels were measured every 2 hours for 24 hours in patients requiring adrenaline therapy for septic shock.
Participant Demographics
Patients requiring adrenaline therapy for septic shock, acquired more than 24 hours after ICU admission.
Statistical Information
P-Value
P = 0.009
Confidence Interval
95% CI = 1.03 to 1.26
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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