Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
2011
CITCO inhibits growth of brain tumor stem cells
publication
Evidence: moderate
Author Information
Author(s): Chakraborty S, Kanakasabai S, Bright J J
Primary Institution: Methodist Research Institute
Hypothesis
Targeting BTSCs with CAR agonist CITCO.
Conclusion
CITCO inhibits the growth and expansion of brain tumor stem cells, suggesting its potential use in treatment.
Supporting Evidence
- CITCO induced a dose-dependent decrease in growth and expansion of CD133+ BTSCs.
- CITCO caused cell cycle arrest and apoptosis in BTSCs.
- CITCO inhibited the growth of BTSC xenografts in nude mice.
Takeaway
CITCO is a special medicine that helps stop bad brain cells from growing, which can help treat brain tumors.
Methodology
The study used quantitative RT-PCR, western blot, WST-1 and 3H thymidine uptake assays, immunostaining, flow cytometry, and in vivo xenograft models.
Limitations
The study primarily focuses on in vitro and animal models, which may not fully represent human responses.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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