S100P Protein in Normal and Cancerous Tissues
Author Information
Author(s): Seppo Parkkila, Pei-wen Pan, Aoife Ward, Adriana Gibadulinova, Ingrid Oveckova, Silvia Pastorekova, Jaromir Pastorek, Alejandra Rodriguez Martinez, Henrik O Helin, Jorma Isola
Primary Institution: Institute of Medical Technology, University of Tampere and Tampere University Hospital
Hypothesis
S100P may serve as a potential tumor biomarker due to its expression in various cancers.
Conclusion
S100P is widely expressed in both normal and malignant tissues, indicating its potential as a target for diagnostic and therapeutic applications.
Supporting Evidence
- S100P mRNA levels were highest in the placenta and esophagus among normal tissues.
- S100P protein was expressed in all tumor categories studied, with the highest prevalence in gastric tumors.
- The study utilized a novel monoclonal antibody for S100P to confirm its expression in various tissues.
Takeaway
S100P is a protein found in many body tissues, and it shows up a lot in certain cancers, which might help doctors find and treat these cancers better.
Methodology
S100P expression was examined using quantitative reverse transcription polymerase chain reaction and immunohistochemistry in various normal and tumor tissues.
Limitations
The study does not explore the functional role of S100P in detail or its potential variations in different cancer types.
Digital Object Identifier (DOI)
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