Modeling Late Rectal Bleeding After Prostate Cancer Radiotherapy
Author Information
Author(s): Christian A.M. Jongen, Ben J.M. Heijmen, Wilco Schillemans, Andras Zolnay, Marnix G. Witte, Floris J. Pos, Ben Vanneste, Ludwig J. Dubois, David van Klaveren, Luca Incrocci, Wilma D. Heemsbergen
Primary Institution: Erasmus MC Cancer Institute, University Medical Center Rotterdam
Hypothesis
To develop a single NTCP model for grade ≥2 late rectal bleeding after conventional or hypofractionated radiotherapy for prostate cancer.
Conclusion
The study found that EUD (n=0.1), D0.1cm3, and D2cm3 models were the best predictors for late rectal bleeding.
Supporting Evidence
- The study analyzed data from a randomized trial with both conventional and hypofractionated radiotherapy.
- Models based on EUD (n=0.1), D0.1cm3, and D2cm3 showed the best predictive performance.
- 14% of patients experienced grade ≥2 late rectal bleeding.
Takeaway
This study helps doctors understand how different radiation treatments for prostate cancer can affect the risk of bleeding in the rectum.
Methodology
The study used logistic regression models to analyze data from prostate cancer patients treated with different radiation schedules.
Limitations
The sample size was limited to 656 patients and lacked information on cardiovascular history.
Participant Demographics
Intermediate- to high-risk prostate cancer patients, with a total of 656 included in the analysis.
Statistical Information
P-Value
0.007
Statistical Significance
p=0.007
Digital Object Identifier (DOI)
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