Human Pregnane X Receptor in Breast Cancer
Author Information
Author(s): Conde Isabel, Lobo María VT, Zamora Javier, Pérez Julio, González Francisco J, Alba Emilio, Fraile Benito, Paniagua Ricardo, Arenas María I
Primary Institution: Department of Cell Biology and Genetics, University of Alcalá
Hypothesis
The expression profile of hPXR and RXRs in localized infiltrative breast cancer is associated with an increased risk of recurrent disease.
Conclusion
The overexpression and subcellular location changes of hPXR could be considered as a potential new prognostic indicator in breast cancer.
Supporting Evidence
- Patients with recurrent disease showed a high cytoplasmic location of hPXR isoforms.
- Infiltrative carcinomas that relapsed before 48 months showed nuclear location of hPXR isoform 2.
- The expression of hPXR was not significantly altered during tumorigenesis.
- Patients with nuclear hPXR expression had a higher risk of recurrence.
Takeaway
This study found that a specific protein, hPXR, is present in breast cancer cells and its location in the cell can help predict if the cancer will come back.
Methodology
Breast samples from 99 patients were processed for immunohistochemistry and Western-blot analysis.
Potential Biases
Potential biases in patient selection and sample processing.
Limitations
The study may not account for all variables affecting breast cancer recurrence.
Participant Demographics
Patients aged 35 to 91 years diagnosed with localized breast cancer.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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