Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma
Author Information
Author(s): Dean Nichole R., Sweeny Larissa, Magnuson J. Scott, Carroll William R., Robinson Daniel, Desmond Renee A., Rosenthal Eben L.
Primary Institution: The University of Alabama at Birmingham
Hypothesis
What are the outcomes for patients with recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) of the head and neck?
Conclusion
Patients with recurrent advanced stage cSCC have poor prognosis and low disease-free survival rates despite aggressive treatment.
Supporting Evidence
- Two-year disease-free survival was 62% and decreased to 47% at 5 years.
- Distant metastasis was a strong indicator of poor overall survival (P < .001).
- Adjuvant postoperative radiotherapy did not improve overall survival (P = .42).
Takeaway
This study looked at patients with a type of skin cancer that keeps coming back, and found that even with surgery and radiation, many of them still had a hard time staying cancer-free.
Methodology
A retrospective review of patients who underwent surgical resection for recurrent, advanced stage cSCC was performed, analyzing various clinical and treatment factors.
Limitations
The study is retrospective and may not account for all variables affecting outcomes.
Participant Demographics
The majority of patients were male (85%) with a mean age of 71 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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