Catalysts for Selective Fluorination of Thiazolidinones
Author Information
Author(s): Ishimaru Takehisa, Shibata Norio, Reddy Dhande Sudhakar, Horikawa Takao, Nakamura Shuichi, Toru Takeshi
Primary Institution: Nagoya Institute of Technology
Hypothesis
Can DBFOX-Ph/metal complexes effectively catalyze the enantioselective fluorination of 3-(2-arylacetyl)-2-thiazolidinones?
Conclusion
DBFOX-Ph/Ni(II) catalysis can achieve good to high yields and moderate to good enantioselectivities in the fluorination of thiazolidinones.
Supporting Evidence
- The optimal reaction conditions yielded fluorinated products in good to high yields.
- Enantioselectivities reached up to 78% ee under specific conditions.
- The study demonstrated the effectiveness of DBFOX-Ph/Ni(II) in catalyzing the reaction.
Takeaway
This study shows a way to make special chemicals that have a fluorine atom in them, which can be useful in medicine and materials.
Methodology
The study evaluated the catalytic enantioselective fluorination of thiazolidinones using DBFOX-Ph/metal complexes and N-fluorobenzenesulfonimide under various conditions.
Limitations
The enantioselectivity achieved was lower than that reported in previous studies using different catalysts.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website