The Bet v 1 fold: a versatile scaffold for binding large ligands
Author Information
Author(s): Radauer Christian, Lackner Peter, Breiteneder Heimo
Primary Institution: Medical University of Vienna
Hypothesis
We aimed to identify and classify all Bet v 1-related structures and sequences.
Conclusion
The widespread presence of Bet v 1-related proteins suggests they originated from a common ancestor and evolved to bind various large ligands.
Supporting Evidence
- 47 structures related to Bet v 1 were identified and classified into 11 families.
- Five new families were identified that were not included in previous classifications.
- Bet v 1-related proteins are distributed across all three superkingdoms.
Takeaway
Scientists studied a protein called Bet v 1 that helps plants deal with stress and found it can bind to many different substances, showing it has been around for a long time.
Methodology
The study involved structural comparisons and classifications of Bet v 1-related proteins from databases.
Limitations
The study may not cover all Bet v 1-related proteins due to database limitations.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website