Effects of Pulsed Focused Ultrasound on Muscle Tissue in Mice
Author Information
Author(s): Burks Scott R., Ziadloo Ali, Hancock Hilary A., Chaudhry Aneeka, Dean Dana D., Lewis Bobbi K., Frenkel Victor, Frank Joseph A.
Primary Institution: National Institutes of Health, Bethesda, Maryland, United States of America
Hypothesis
What are the cellular and molecular responses of muscle tissue to pulsed focused ultrasound (pFUS) compared to continuous focused ultrasound (cFUS)?
Conclusion
Pulsed focused ultrasound induces molecular changes in muscle tissue and macrophage infiltration without causing tissue destruction.
Supporting Evidence
- Pulsed focused ultrasound (pFUS) has little effect on muscle integrity compared to continuous focused ultrasound (cFUS).
- Macrophage infiltration was observed in both pFUS and cFUS treated muscles.
- Cytokine levels returned to baseline by day 3 post-pFUS treatment.
Takeaway
This study shows that pulsed focused ultrasound can help deliver treatments to muscles without hurting the tissue, which is good for healing.
Methodology
Mice were treated with pulsed or continuous focused ultrasound, and tissue was analyzed for cytokine expression and macrophage infiltration.
Potential Biases
Potential bias in the interpretation of histological and MRI data.
Limitations
The study was limited to a mouse model, and results may not directly translate to humans.
Participant Demographics
Female C3H mice, approximately 16 weeks old.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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