VEGF Levels During Menstrual Cycle
Author Information
Author(s): McIlhenny C, George W D, Doughty J C
Primary Institution: University Department of Surgery, Western Infirmary, Glasgow, UK
Hypothesis
Do serum and plasma levels of vascular endothelial growth factor (VEGF) vary during the menstrual cycle in healthy pre-menopausal women?
Conclusion
The study found no significant difference in serum or plasma concentrations of VEGF during the menstrual cycle in healthy volunteers.
Supporting Evidence
- Serum VEGF levels were significantly higher than plasma VEGF levels.
- The majority of plasma VEGF measurements were below the detection limit of the ELISA kit.
- Progesterone and oestradiol levels were significantly higher in their respective phases of the menstrual cycle.
Takeaway
The study looked at blood samples from women to see if a substance called VEGF changes during their monthly cycle, but it didn't find any big changes.
Methodology
Blood samples were taken from 20 healthy pre-menopausal women over one menstrual cycle, with serum and plasma analyzed for VEGF and sex hormones.
Limitations
Most plasma VEGF measurements were below the detection limit of the ELISA kit, making it difficult to draw conclusions about plasma levels.
Participant Demographics
Twenty healthy pre-menopausal women aged 28 to 47 with regular menstrual cycles.
Statistical Information
P-Value
p<0.005
Confidence Interval
95% Confidence interval 39.9
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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