Cocrystals of Apremilast with Phenolic Compounds
Author Information
Author(s): Yelizaveta Naumkina, Bohumil Kratochvíl, Elena Korotkova, Jan Čejka
Primary Institution: University of Chemistry and Technology, Prague
Hypothesis
Can cocrystallization of Apremilast with phenolic coformers improve its solubility?
Conclusion
The study found that the cocrystals of Apremilast with phenolic compounds exhibited minimal differences in melting points despite variations in the coformers' hydroxyl groups.
Supporting Evidence
- Four novel cocrystal forms were synthesized and characterized.
- The cocrystals crystallized in the same space group P41212.
- Despite expectations, the number of hydroxyl groups did not significantly affect molecular packing.
- Thermal analysis indicated the stability of the new solid forms.
Takeaway
Scientists mixed a medicine called Apremilast with some plant-based compounds to see if it would dissolve better, but they found that it didn't change much.
Methodology
Cocrystallization of Apremilast with four phenolic coformers was performed, followed by characterization using X-Ray diffraction and thermal analysis techniques.
Limitations
The variability in molecular packing did not change with the increasing number or variety of hydroxyl groups in the coformers.
Digital Object Identifier (DOI)
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