Antitumour Activity of Novel Triphenyltin Compounds
Author Information
Author(s): Marcel Gielen, Abdelaziz El Khloufi, Monique Biesemans, Abdeslam Bouhdid, Dick de Vos, Bernard Mahieu, Rudolph Willem
Primary Institution: Free University of Brussels (V.U.B.)
Hypothesis
The nature and substitution pattern of the aromatic ring of the carboxylate moiety influences the antitumour activity of triphenyltin compounds.
Conclusion
The novel triphenyltin compounds demonstrated higher antitumour activity than several clinically used drugs against two human tumour cell lines.
Supporting Evidence
- Three novel triphenyltin compounds were synthesized and tested.
- These compounds showed greater activity than cis-platin, etoposide, and doxorubicin.
- They were as effective as mitomycin C against the WiDr cell line.
Takeaway
Scientists created new triphenyltin compounds and found they work better than some common cancer drugs in fighting certain types of cancer cells.
Methodology
The compounds were synthesized through a condensation reaction and their antitumour activity was tested against two human tumour cell lines.
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