Regulation of CCL18 Secretion in Rheumatoid Arthritis
Author Information
Author(s): Antoine WT van Lieshout, Robbert van der Voort, Linda MP Blanc, Mieke F Roelofs, B Willem Schreurs, Piet LCM van Riel, Gosse J Adema, Timothy RDJ Radstake
Primary Institution: Radboud University Nijmegen Medical Centre, The Netherlands
Hypothesis
The study investigates the regulation of CCL18 secretion by monocytes and dendritic cells in the context of rheumatoid arthritis.
Conclusion
IL-10 synergistically induces CCL18 secretion in combination with IL-4 or IL-13 on monocytes, and this effect is strongly enhanced by synovial fluid from RA patients.
Supporting Evidence
- IL-10 strongly stimulated dendritic cells to secrete CCL18.
- CCL18 secretion was induced by IL-4 and IL-13 in synergy with IL-10.
- RA synovial fluid enhanced CCL18 secretion significantly.
Takeaway
This study shows that certain proteins can help immune cells make more of a chemical called CCL18, which is important in diseases like rheumatoid arthritis.
Methodology
The study involved stimulating monocytes and dendritic cells with various cytokines and measuring CCL18 secretion.
Participant Demographics
Participants included healthy volunteers and rheumatoid arthritis patients.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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