Effects of Somatostatin Analogue on Hormones in Carcinoid Tumours
Author Information
Author(s): B. Wangberg, O. Nilsson, E. Theodorsson, A. Dahlström, H. Ahlman
Primary Institution: University of Goteborg and Karolinska Hospital
Hypothesis
Does the somatostatin analogue SMS 201-995 reduce hormone secretion from human midgut carcinoid tumour cells?
Conclusion
The somatostatin analogue SMS 201-995 significantly reduces the secretion of serotonin and tachykinins from human midgut carcinoid tumour cells without affecting cell growth.
Supporting Evidence
- SMS treatment reduced media concentrations of serotonin by 56%.
- Intracellular serotonin levels decreased by 27% after SMS treatment.
- DNA contents of cultures were not affected by SMS treatment.
Takeaway
A medicine called SMS 201-995 helps lower the amount of certain hormones made by cancer cells in the gut, which can help patients feel better.
Methodology
The study involved culturing human midgut carcinoid tumour cells and treating them with SMS 201-995 to measure changes in hormone levels.
Limitations
The study was limited to four patients and may not represent broader populations.
Participant Demographics
Four patients with metastatic carcinoid disease, ages 45 to 68, including both males and females.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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