CHD5 Regulates Neuronal Genes
Author Information
Author(s): Rebecca Casaday Potts, Peisu Zhang, Andrea L. Wurster, Patricia Precht, Mohamed R. Mughal, William H. Wood III, Yonqing Zhang, Kevin G. Becker, Mark P. Mattson, Michael J. Pazin
Primary Institution: National Institute on Aging Intramural Research Program, National Institutes of Health
Hypothesis
What is the role of CHD5 in regulating neuronal gene expression?
Conclusion
CHD5 is a brain-specific protein that regulates the expression of genes linked to aging and Alzheimer's disease.
Supporting Evidence
- CHD5 mRNA is primarily found in the brain and not in other tissues.
- Depletion of CHD5 alters the expression of genes linked to aging and Alzheimer's disease.
- CHD5 is part of a NuRD-like complex that includes proteins associated with chromatin remodeling.
Takeaway
CHD5 is a special protein found in the brain that helps control how other brain genes work, especially those related to getting older and Alzheimer's.
Methodology
The study involved analyzing CHD5 expression in rat brain and neurons, using techniques like microarray analysis and chromatin immunoprecipitation.
Limitations
The study did not explore all possible cell types or developmental stages for CHD5 expression.
Participant Demographics
The study focused on rat brain and primary neurons.
Digital Object Identifier (DOI)
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