IL-11 and Lung Inflammation in Tuberculosis
Author Information
Author(s): Marina A. Kapina, Galina S. Avdeenko, Vadim G. Guseva, Anna N. Kondratieva, Tatiana K. Evstifeev, Vladimir V. Apt, Alexander S. Apt
Primary Institution: Central Institute for Tuberculosis, Moscow, Russia
Hypothesis
Blocking IL-11 will reduce lung inflammation and pathology in tuberculosis-infected mice.
Conclusion
Blocking IL-11 reduces lung inflammation and improves outcomes in tuberculosis-infected genetically susceptible mice.
Supporting Evidence
- Blocking IL-11 diminished histopathology and neutrophilic infiltration in the lungs of TB-infected mice.
- Antibody treatment decreased pulmonary levels of IL-11 and other inflammatory cytokines.
- IL-11 mRNA expression was down-regulated in treated mice, suggesting a feedback loop.
Takeaway
This study shows that a substance called IL-11 makes lung problems worse in mice with tuberculosis, and stopping it helps the mice feel better.
Methodology
The study used genetically susceptible mice infected with Mycobacterium tuberculosis and treated them with anti-IL-11 antibodies to assess inflammation and pathology.
Limitations
The study was conducted in mice, which may not fully replicate human responses to tuberculosis.
Participant Demographics
Female I/StSnEgYCit mice aged 9–10 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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