Silent Venous Thromboembolism in Endometrial Cancer
Author Information
Author(s): Satoh T, Matsumoto K, Uno K, Sakurai M, Okada S, Onuki M, Minaguchi T, Tanaka Y O, Homma S, Oki A, Yoshikawa H
Primary Institution: University of Tsukuba, Ibaraki, Japan
Hypothesis
What is the incidence of venous thromboembolism (VTE) before treatment in patients with endometrial cancer and what are the associated risk factors?
Conclusion
Silent or subclinical VTE occurs before treatment in at least around 10% of patients with endometrial cancer.
Supporting Evidence
- 21.6% of patients showed elevated D-dimer levels indicating potential VTE.
- 9.9% of patients were found to have deep vein thrombosis (DVT) before treatment.
- 4.7% of patients showed pulmonary thromboembolism (PTE) on scintigraphy.
- Older age and non-endometrioid histology were significantly associated with VTE.
Takeaway
Some patients with endometrial cancer have blood clots before they even start treatment, and we need to check for them to keep patients safe.
Methodology
Plasma D-dimer levels were measured and venous ultrasound imaging was performed on patients with elevated D-dimer levels to detect VTE.
Limitations
The study may not have detected all cases of VTE as ultrasound imaging was only performed on patients with elevated D-dimer levels.
Participant Demographics
Mean age was 58.1 years, with a range from 19 to 84 years.
Statistical Information
P-Value
0.009
Statistical Significance
p=0.009
Digital Object Identifier (DOI)
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