Donor Selection in Stem Cell Transplantation
Author Information
Author(s): Shike Hiroko, Zhang Aiwen
Primary Institution: Penn State Milton S. Hershey Medical Center
Hypothesis
How do HLA and non-HLA factors influence donor selection for hematopoietic stem cell transplantation with post-transplant cyclophosphamide?
Conclusion
HLA matching is less critical under post-transplant cyclophosphamide, allowing haploidentical and mismatched unrelated donors to be acceptable.
Supporting Evidence
- HLA mismatches can be tolerated with post-transplant cyclophosphamide for GvHD prophylaxis.
- Younger donors improve survival outcomes.
- High donor-specific antibody levels increase the risk of engraftment failure.
Takeaway
When choosing a donor for stem cell transplants, it's okay to pick someone who doesn't match perfectly because new treatments make it safer.
Methodology
This is a review article assessing factors influencing donor selection based on recent findings and consensus recommendations.
Limitations
The data on the impact of HLA and non-HLA factors is insufficient to rank them for hierarchy in donor selection.
Digital Object Identifier (DOI)
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