Oncogenic Pathway Signatures in Prostate Cancer
Author Information
Author(s): Chad J. Creighton
Primary Institution: Baylor College of Medicine
Hypothesis
Human prostate tumors with high mRNA levels of a given oncogene should also show high levels of the group of genes found over-expressed in the experimental setting when the same oncogene is turned up.
Conclusion
Significant subsets of the genes in these experimentally-derived oncogenic signatures are relevant to the study of human prostate cancer.
Supporting Evidence
- Genes up-regulated experimentally by Myc, c-Src, HER2, Akt, or androgen were co-expressed in human prostate tumors.
- Significant overlap was observed between oncogenic signatures and human tumor correlates.
- Patterns of enrichment were found in three of the four datasets examined.
Takeaway
This study looked at how certain cancer-related genes behave in prostate tumors, finding that some genes act similarly in both lab models and real tumors.
Methodology
Gene expression profiles from four datasets of human prostate tumors were analyzed using Q1-Q2 and one-sided Fisher's exact enrichment analysis methods.
Limitations
No consistent patterns were found in all four datasets, which could be due to technical or biological reasons.
Participant Demographics
The study involved gene expression data from approximately 250 patients with prostate cancer.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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