Medicinal Cannabis and the Intestinal Microbiome
Author Information
Author(s): Vitetta Luis, Nation Tamara, Oldfield Debbie, Thomsen Michael
Primary Institution: Faculty of Medicine and Health, The University of Sydney
Hypothesis
The intestinal microbiota is an interconnecting axis between the ECS and ingested medicinal cannabis molecules that can then mediate neuro-immunomodulation.
Conclusion
Medicinal cannabis may improve health outcomes by interacting with the intestinal microbiome and the endocannabinoid system.
Supporting Evidence
- The intestinal microbiota can influence the pharmacological effects of cannabinoids.
- Intestinal dysbiosis may affect the efficacy of medicinal cannabis treatments.
- Clinical studies suggest that cannabis can improve gut motility and reduce inflammation.
Takeaway
This study suggests that the bacteria in our gut can affect how well medicinal cannabis works, and that cannabis might help with gut health.
Methodology
The study reviews existing literature on the interactions between medicinal cannabis, the intestinal microbiome, and the endocannabinoid system.
Potential Biases
Potential conflicts of interest due to authors' involvement in cannabis-related research and clinical practice.
Limitations
Clinical evidence is limited and primarily based on surveys and small trials.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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