Molecular and Cellular Effects of C-peptide

publication Evidence: moderate

Author Information

Author(s): John Wahren, Jawed Shafqat, Jan Johansson, Alexander Chibalin, Karin Ekberg, Hans Jörnvall

Primary Institution: Karolinska Institutet, Stockholm, Sweden

C-peptide is a biologically active peptide hormone that may have beneficial effects in type 1 diabetes.

C-peptide replacement therapy may improve renal and nerve function in patients with type 1 diabetes.

C-peptide binds specifically to cell membranes and activates intracellular signaling pathways.
Replacement of C-peptide improves renal and nerve function in type 1 diabetes patients.
C-peptide stimulates Na+,K+-ATPase and endothelial nitric oxide synthase activities.
C-peptide may interact synergistically with insulin on the insulin signaling pathway.
Clinical evidence suggests that C-peptide replacement may prevent long-term complications in type 1 diabetes.

C-peptide, a part of insulin, can help people with type 1 diabetes feel better by improving how their body works.

The study reviews various experimental and clinical studies on C-peptide's effects on cellular signaling and function.

The study primarily focuses on existing literature and may not include new experimental data.

The study discusses findings primarily in type 1 diabetes patients.

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